![]() The gene expression pattern was analyzed by reverse transcription polymerase chain reaction (RTPCR). BV2 cells were polarized using phosphate-buffered saline (PBS), LPS or IL-4, respectively. We also investigated the potential mechanisms of these pro-angiogenesis effects. The aim of this study was to investigate the pro-angiogenesis effects of unpolarized, interleukin-4 (IL-4)-polarized or lipopolysaccharide (LPS)-polarized BV2 microglia cells both in vivo and in vitro. However, the underlying mechanisms are largely unknown and need further investigation. Microglia cells may play this nerve-protective role via the promotion of angiogenesis. The microglia cell transfer has been shown to play a protective role in ischemic stroke. ![]() Yuan Tian 1,2,B,C,D, Pei Zhu 1,B, Shanshan Liu 1,B, Zheng Jin 1,B, Dong Li 1,E, Heng Zhao 3,A, Xun Zhu 1,A, Chang Shu 4,C, Dongmei Yan 1,A,D,E,F, Zehua Dong 5,A,Fġ Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun, ChinaĢ Key Laboratory of Molecular Enzymology and Engineering under the Ministry of Education, College of Life Sciences, Jilin University, Changchun, Chinaģ Department of Neurosurgery, Stanford University, USAĤ Department of Obstetrics, First Hospital of Jilin University, Changchun, Chinaĥ Intensive Care Unit, the Affiliated Hospital of Qingdao University, Chinaīackground. IL-4-polarized BV2 microglia cells promote angiogenesis by secreting exosomes RIS (Papers, Reference Manager, RefWorks, Zotero).
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